Characterisation of the Family C of G-protein Coupled Receptors

Denne afhandling er af Danmarks Farmaceutiske Højskole antaget til offentligt at forsvares for den farmaceutiske doktorgrad. For Anita, without whose support this would have been much harder. Preface i Preface No Man is an Island. This immortal phrase by John Donne also holds true when it comes to science. Thus the present thesis would not have been possible to write without the many fruitful collaborations I have enjoyed during my research. First of all I would like to express my gratitude to Professor Povl Krogsgaard-Larsen who has been of paramount importance to my research due to his many helpful suggestions and his endless support. I would also like to thank all present and former members of the NeuroMedicinal Chemistry group for their contributions, in particular the co-authors of the papers forming the thesis are gratefully acknowledged. Also I extend my thanks to Heidi Petersen and Anne Nordly for excellent technical and secreterial assistance, respectively. Finally, I thank Drs. Spalding for fruitful discussions and collaborations and Dr. Richard Mountfield for helpful suggestions regarding the thesis manuscript. A new highly selective metabotropic excitatory amino acid agonist: